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Nonapeptide AOP-P1 ameliorates UVB-induced hyperpigmentation by suppressing melanogenesis via targeting natriuretic peptide receptor 2.

  • Aug 15, 2026
Hyperpigmentation disorders remain challenging to treat because most available agents mainly act on downstream melanogenic enzymes rather than upstream regulatory mechanisms. In this study, we identified AOP-P1, an amphibian skin-derived nonapeptide, as a potent anti....Read More

Mechanism of Inonotus hispidus in treating melasma: integrated in vivo, in vitro, network pharmacology and untargeted metabolomics investigation.

  • Jun 12, 2026
Inonotus hispidus (Bull.) P. Karst. is a traditional Chinese medicine (TCM) with a long history. Although its use in treating melasma was documented in the Bencaogangmu, its therapeutic mechanism remains unexplored and is poorly understood in modern research.To inves....Read More

A Comparative Multimodal Approach to Post-Inflammatory Hyperpigmentation After Energy-Assisted Liposuction: Laser Therapy With or Without Hyperbaric Oxygen.

  • May 15, 2026
Inonotus hispidus (Bull.) P. Karst. is a traditional Chinese medicine (TCM) with a long history. Although its use in treating melasma was documented in the Bencaogangmu, its therapeutic mechanism remains unexplored and is poorly understood in modern research.To inves....Read More

Iron Oxides in Tinted Sunscreen for Hyperpigmentation: A Product Analysis and Literature Review.

  • May 01, 2026
Inonotus hispidus (Bull.) P. Karst. is a traditional Chinese medicine (TCM) with a long history. Although its use in treating melasma was documented in the Bencaogangmu, its therapeutic mechanism remains unexplored and is poorly understood in modern research.To inves....Read More

Development of a core outcome set for clinical trials in melasma.

  • Apr 29, 2026
Inonotus hispidus (Bull.) P. Karst. is a traditional Chinese medicine (TCM) with a long history. Although its use in treating melasma was documented in the Bencaogangmu, its therapeutic mechanism remains unexplored and is poorly understood in modern research.To inves....Read More

Comparative effectiveness of acupuncture, fire needle, and herbal therapies for melasma: A Bayesian network meta-analysis.

  • Apr 17, 2026
Inonotus hispidus (Bull.) P. Karst. is a traditional Chinese medicine (TCM) with a long history. Although its use in treating melasma was documented in the Bencaogangmu, its therapeutic mechanism remains unexplored and is poorly understood in modern research.To inves....Read More

Chronic venlafaxine ingestion inducing bluish oral hyperpigmentation with dysgeusia and dysphagia: A case report.

  • Apr 10, 2026
BackgroundMedication-induced oral hyperpigmentation represents an adverse drug reaction characterized by variable latency and unclear mechanism. Diagnosis is particularly challenging in older adults due to non-specific symptoms, multiple comorbidities and polypharmac....Read More

Integrative Analysis Using LC-MS, Network Pharmacology, and Molecular Docking Elucidates the Mechanism of Yurong Fang in Melasma Treatment.

  • Apr 07, 2026
Inonotus hispidus (Bull.) P. Karst. is a traditional Chinese medicine (TCM) with a long history. Although its use in treating melasma was documented in the Bencaogangmu, its therapeutic mechanism remains unexplored and is poorly understood in modern research.To inves....Read More

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